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Trauma nurses in providing nursing care and prevention options
Štrombachová, Veronika ; Nikodemová, Hana (advisor) ; Hlaváčová, Marie (referee)
The thesis is focused on the issue of injury to nurses in providing nursing care and disease, which is due to an injury risk. It also deals with back pain, total prevention of the problems and possibilities of compensation for work injuries. In connection with the issues I have set goals and determine whether the respondents comply with established nursing standards and whether they last three years has been injuries in connection with the provision of nursing care. Furthermore, if the respondents know the correct procedure in injuries of the needle used, whether the value of container used for disposal of infectious waste for safe and whether they suffer from back pain lately. I believe that the specific targets of the thesis managed to meet the total. In a benefit for working professionals could be a picture of the issues presented by the selected workplaces. Suggesting the need to continue to pursue the above-mentioned topic.
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Selected aspects of immunopathogenesis of HIV infection
Bartovská, Zofia ; Holub, Michal (advisor) ; Boštík, Pavel (referee) ; Marešová, Vilma (referee)
Introduction: Virus-specific CD8+ T cells are crucial to suppress the viral replication in HIV infection. Their functional status is important as well. Also, the chronic nonspecific immune activation of T and B lymphocytes plays an important role in the immunopathogenesis of HIV infection. Aim of the study: To analyze the frequency and functional status of HIV-specific CD8+ T cells and the expression of nonspecific activation markers on B and T cells in HIV+ patients and to assess the effect of combined antiretroviral therapy (cART) on these parameters. Patients and methods: Our cohort included 80 HIV+ patients: 36 HIV+ patients on cART, 18 patients without therapy, in whom cART was introduced during our study, 9 patients without therapy, 10 patients with primary HIV infection, 3 long-term non-progressors and 4 patients initially on cART, in whom the therapy was discontinued. Control group consisted of 34 HIV- healthy individuals. We examined CD4+ a CD8+ T cell counts, viral load, expression of nonspecific activation markers on T cells and the frequency of HIV-specific CD8+ T cells by ELISpot method and flow cytometry using MHC tetramers and intracellular cytokine detection. Results: No significant differences in HIV-specific CD8+ T cells were found between treated and untreated HIV+ patients. The frequency...
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Selected aspects of immunopathogenesis of HIV infection
Bartovská, Zofia ; Holub, Michal (advisor) ; Boštík, Pavel (referee) ; Marešová, Vilma (referee)
Introduction: Virus-specific CD8+ T cells are crucial to suppress the viral replication in HIV infection. Their functional status is important as well. Also, the chronic nonspecific immune activation of T and B lymphocytes plays an important role in the immunopathogenesis of HIV infection. Aim of the study: To analyze the frequency and functional status of HIV-specific CD8+ T cells and the expression of nonspecific activation markers on B and T cells in HIV+ patients and to assess the effect of combined antiretroviral therapy (cART) on these parameters. Patients and methods: Our cohort included 80 HIV+ patients: 36 HIV+ patients on cART, 18 patients without therapy, in whom cART was introduced during our study, 9 patients without therapy, 10 patients with primary HIV infection, 3 long-term non-progressors and 4 patients initially on cART, in whom the therapy was discontinued. Control group consisted of 34 HIV- healthy individuals. We examined CD4+ a CD8+ T cell counts, viral load, expression of nonspecific activation markers on T cells and the frequency of HIV-specific CD8+ T cells by ELISpot method and flow cytometry using MHC tetramers and intracellular cytokine detection. Results: No significant differences in HIV-specific CD8+ T cells were found between treated and untreated HIV+ patients. The frequency...
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Trauma nurses in providing nursing care and prevention options
Štrombachová, Veronika ; Nikodemová, Hana (advisor) ; Hlaváčová, Marie (referee)
The thesis is focused on the issue of injury to nurses in providing nursing care and disease, which is due to an injury risk. It also deals with back pain, total prevention of the problems and possibilities of compensation for work injuries. In connection with the issues I have set goals and determine whether the respondents comply with established nursing standards and whether they last three years has been injuries in connection with the provision of nursing care. Furthermore, if the respondents know the correct procedure in injuries of the needle used, whether the value of container used for disposal of infectious waste for safe and whether they suffer from back pain lately. I believe that the specific targets of the thesis managed to meet the total. In a benefit for working professionals could be a picture of the issues presented by the selected workplaces. Suggesting the need to continue to pursue the above-mentioned topic.
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